Ronaldo's great start in Russian Federation allowed him to surpass the combined total of three goals he had scored in his previous three World Cups.
Ronaldo was unable to trouble Uruguay as they made it through to the quarter-final against France and, at 33, with a 154 caps to his name, this could represent a natural watershed.
But Uruguay were back in front seven minutes later when Rodrigo Betancur allowed Cavani to brilliantly curl home his 45th worldwide goal.
Portugal hasn't reached the World Cup quarterfinals since 2006, when a young Ronaldo led the team to the semifinals.
Cavani had been instrumental in his side's performance to that point, having opened the scoring in the seventh minute after making an excellently timed run to get on the end of a cross into the area by fellow forward Luis Suarez. The South Americans work the ball to Cavani who has time to consider his options on the edge of the box. he wraps his body around the ball, curling an unstoppable shot into the top corner.
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Another poster has a letter from Geoffrey that reads: 'One day, all of us will get separated from each other. Jacob Rabon IV tweeted two of the photos with the caption: 'I can't believe childhood is cancelled'.
Japan advance despite loss to Poland
Poland , for the third straight World Cup that it has competed in, lost its first two group matches and then won its third. Nevertheless, Japan were unable to find an equaliser in the closing stages as Poland held on for the win.
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Certainly, some top Democrats - notably, veteran lawmakers - said Tuesday's results don't indicate a need for wholesale changes. For example, she held back during Elmore's weekly forums to hear others speak before sharing her views, Fernandez remembers.
Cavani scored twice and Ronaldo none Saturday to give Uruguay a 2-1 victory over Portugal.
Taking to Twitter after the game, one viewer said: "Ronaldo just said F*** YOU to a referee".
This has been his best World Cup in terms of goals scored, as he leaves with four in total, including a hat-trick in a 3-3 draw with Spain in the group stage. After winning the free kick 30 yards from goal, Suarez drilled the dead-ball restart low, bouncing it through the wall and just inside Patricio's left-hand post, but the Wolverhampton Wanderers man (signed this summer) came saw it the whole way.
Despite the disappointment of exiting a World Cup early - meaning he will be denied the elusive piece of silverware missing from his trophy cabinet - Ronaldo managed a smile for the cameras.
With or without Cavani, though, Uruguay will make it tough for France and should not be written off.
Cristiano congratulated Uruguay, FIFA and Russian Federation for the hosting of the World Cup, while refusing to make a fuss about his future with the national team.