And given Raonic was the last man to beat Federer at Wimbledon, that might provide hope to those players. "You have to win the last point, and I didn't succeed in that today".
The 38-year-old American - last year's runner-up at Wimbledon - was the oldest entrant in the women's singles field.
She rallied to level the third-round match before Rodina sealed a maiden place in the last 16 of a major.
Ekaterina Makarova of Russian Federation also reached the fourth round, following up her victory over second-seeded Caroline Wozniacki with a 4-6, 6-4, 6-1 win over former semifinalist Lucie Safarova of the Czech Republic.
Three-time champion Novak Djokovic also marched on.
Ken Skupski was back in action later in the day, alongside fellow Brit Anna Smith, to make it through to the mixed doubles second round with a 6-1 6-7 (3-7) 7-5 victory over Nicholas Monroe and Oksana Kalashnikova.
Williams is the fourth former women's champion to get knocked out, joining Maria Sharapova, Petra Kvitova and last year's victor Garbine Muguruza.
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In 2009 he wrote a book about his experiences of growing up in Paris's crime-ridden suburbs and graduating into a life of crime. Before that incident, Faid had been released from prison after convincing the parole board that he renounced his criminal past.
Wolff rues Austrian double DNF for Mercedes
On lap 53, he pitted again for super-softs, dropping a place to fifth behind Ricciardo, who nearly immediately slowed and stopped. While both Red Bulls and Ferraris went to their boxes to have their tires changed, Mercedes surprisingly let Hamilton driving on.
Basketball: LeBron James signs deal to play with LA Lakers
The massive Los Angeles market will also provide James with a grander platform for his philanthropy and social activism. The Lakers have a young, talented but inexperienced roster and they were hoping to land both James and possibly George.
The big Argentine, in the same half of the draw as Nadal, was dominant throughout against the 36-year-old at his 66th consecutive grand slam tournament.
Anderson had a two sets to one lead when rain interrupted his charge on Wednesday night, but came out firing on Thursday and quickly won the fourth set.
Federer next faces French 22nd seed Adrian Mannarino.
The South African eighth seed reached the third round when he completed a four-set victory over Italy's Andreas Seppi on Thursday.
Serena took her Wimbledon winning streak to 17 matches, thanks in part to 13 aces.
"I worked really, really hard (to get back playing) and it's been a long, arduous road but I always expected to come out and do the best I can do".
Nadal will be up against the promising Alex de Minaur, who beat Pierre Hugues Herbert 6-2, 6-7 (8), 7-5, 6-3.
The 23-year-old American threatened a remarkable comeback in the third-round contest, coming from a set and 4-0 down to force a decider.