On March 20, she met with top executives of technology companies including Amazon, Google, Twitter, Snap and Facebook, to discuss the issue of cyberbullying and how it affects children.
Her son, Barron, did not accompany her on the trip.
The trip is Melania Trump's first major solo outing overseas as first lady.
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Earlier Tuesday she visited a baby clinic in Ghana to highlight her interest in child welfare.
She was met by her Ghanaian counterpart Rebecca Akufo-Addo and a group of local schoolchildren in yellow and brown uniforms waving the United States stars and stripes and the Ghanaian flag. They exchanged gifts: a Chippendale silver tray embossed with an image of the White House inside a leather case signed by "First Lady Melania Trump" for Akufo-Addo, and Kente cloth and artifacts for Mrs. Trump, according to Grisham.
The first ladies met privately at Ghana's presidential palace, the Jubilee House after meeting for the first time at the United Nations General Assembly meeting in NY last week.
In her week-long visit of Africa, Melania is expected to also tour Kenya, Malawi and Egypt. It's been a challenging week for the president, and this visit can take some of the focus off that.