"As a precautionary measure, Heathrow Airport has stopped departures and officers based at Heathrow are now investigating the reports with colleagues from Heathrow Airport", she added.
"As a precautionary measure, we have stopped departures while we investigate".
"We continue to monitor this situation and apologise to any passengers that were affected by this disruption", it added.
Heathrow Airport is a crossroads for the world, serving 78 million passengers in 2017.
ITV reporter Sarah Rogers said her plane's pilot grounded her flight to Manchester while police "investigate possible drone activity".
London's Heathrow Airport briefly halted departing flights on Tuesday after a reported drone sighting - a development that came just three weeks after multiple reports of drone sightings caused travel chaos at nearby Gatwick Airport.
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Departures at Heathrow Airport have been stopped after a drone was sighted.
He said: "We continue to work closely with the Met Police to respond to reports of drones at Heathrow".
Arriving planes are continuing to land at Heathrow.
Ministers are now exploring the use of military grade jammers and blocking systems to bring down rogue drones, such as the Israeli Drone Dome system reported to have been deployed at Gatwick.
Gatwick and Heathrow officials have pledge to invest in anti-drone technology, with United Kingdom transport secretary Chris Grayling saying to Parliament on Monday to extend drone exclusion zones near United Kingdom airports.
Whoever had their fun with a drone at Gatwick is about to hand loads more anti-drone powers to the police, as the Home Office has announced the results of a consultation into What To Do About Drones. The government will also extend drone exclusion zones around airports.
Police could also fine drone users failing to comply with authorities or present registration to operate a drone up to £100.