Loew made the announcement with Germany to host Serbia on March 20 in a friendly, then play a Euro 2020 qualifier away to the Netherlands four days later and wants a "new start".
"The young national team players will have the space they need to fully develop".
'It was important for me to personally explain my decision to the players and the FC Bayern management'.
"They are all still world-class players who are at the forefront of their club and guarantee success".
'2019 is a new beginning for the Germany national team, ' he said.
Boateng was one of the key figures in Germany's successful World Cup campaign in Brazil five years ago, starting the final at centre-back alongside Hummels.
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David De Gea conceded twice on the day, but it was two stunning strikes that made him get the ball out of his net. It was a truly magnificent afternoon for Andreas Pereira as well.
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Germany boss Joachim Low reportedly travelled down to Munich to inform the trio who play for Bayern Munich about his decision to drop them from the national team. "Now it's up to them to take responsibility".
And, DFB president Reinhard Grindel also spoke out on the decision, declaring: "I appreciate that Joachim wants to carry on changing the shape of the national side".
"Thomas, Mats and Jerome have achieved a lot until now for German football", Germany team manager Oliver Bierhoff added.
Muller, 29, amassed 100 national team appearances, scoring 38 goals and registering 36 assists since making his debut in 2010 - while Boateng and Hummels picked up 76 and 70 caps respectively.
"I am sad about this news because it has always been the greatest thing for me to represent my country", the defender wrote on Instagram.
After an extremely disappointing World Cup campaign for Germany in 2018, Mesut Ozil was first to announce his retirement from worldwide football.
"I was young myself and reliant on older players to make room for me".
"I was always extremely proud to wear the national team top ands I will never forget the summer of 2014". Of course, I would have wished for another farewell for us. Joachim Low dealt one of the biggest pre tournament shocks by not picking Leroy Sane, despite his brilliant season for Manchester City, but still had a star studded squad.